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| Id: | 18233
| | Autor: | Bach, Marie Anne; Chatenoud, Lucienne; Wallach, D; Phan Dinh Tuy, Françoise; Cottenot, F
| | Título: | Studies on T cell subsets and functions in leprosy
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| | Fonte: | s.l; s.n; jun. 1981. 10 p. tab, graf.
| | Resumo: | T cell subsets and T cell functions were explored in 31 leprosy patients with the following methods: determination of the percentages of the different T cell subpopulations defined by monoclonal antibodies directed at total T cells, helper T cells and suppressor/cytotoxic T cells; measurement of the in vitro proliferative responses to mitogens; study of the concanavalin A-induced suppressive activity, assessed on MLC; measurement of delayed-type hypersensitivity by skin testing. The confrontation between immunological lepromatous patients without type-2 reaction (erythema nodosum leprosum), (2) lepromatous patients without ENL (erythema nodosum leprosum), (2) lepromatous patients was recent ENL and (3) tuberculoid patients. Unexpectedly, groups 1 and 3, although differing strongly in their clinical status and their sensitivity to lepromin (absent in group 1 and strong in group 3), showed a similar immunological profile with a normal percentage of T cells and a normal distribution of T cells among the major T cell subset contrasting with a moderate decrease of proliferative responses to mitogens and impaired delayed-type hypersensitivity reactions. Concanavalin A-induced suppressive activity was type-2 reaction) strongly differed from both other groups, showing striking abnormalities other groups, showing striking abnormalities of the repartition of the T cell subsets, with increased percentages of helper T cells and decreased percentages of suppressor T cells, and elevated proliferative responses to mitogens. Concanavalin A-induced suppressive activity was reduced in most patients of this group. It is suggested that this imbalance between T cell subsets contributes to the occurrence of ENL reactions in lepromatous patients.(AU).
| | Descritores: | ANTICORPOS MONOCLONAIS/imunol
HANSENIASE/imunol
TESTES INTRADERMICOS
CONTAGEM DE LEUCOCITOS
TRANSFORMACAO LINFOCITICA
LINFOCITOS T/clas
LINFOCITOS T/imunol
LINFOCITOS T SUPRESSORES-EFETORES/imunol
CONCANAVALINA A/farmacol
| | Limites: | HUMANO
MASCULINO
FEMININO
ADULTO
MEIA-IDADE
IDOSO
SUPPORT, NON-U.S. GOV'T
ADOLESCENTE
| | Meio Eletrônico: | - .
| | Localização: | BR191.1; 01450/s |
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